Natural Plaque Regression: How to Clean Your Arteries Without Surgery

Cardiovascular disease remains one of the leading causes of death worldwide, with plaque buildup in arteries contributing to heart attacks and strokes. While many people rely on stents or medications, recent research has highlighted numerous natural therapies that can help regress plaque and improve cardiovascular health—without invasive procedures​.

Let’s dive into 15 evidence-based strategies for reversing plaque and maintaining optimal heart health.

What Causes Plaque Buildup in Arteries?

Plaque forms in arteries due to inflammation, high blood pressure, poor diet, smoking, stress, and a sedentary lifestyle. Over time, cholesterol, calcium, and other substances accumulate in the arterial walls, leading to blockages that can trigger heart attacks or strokes​.

The most dangerous arteries to clog include:

• Coronary arteries (heart) – Especially the left descending artery ("Widow Maker").

• Carotid arteries (neck) – Blockages here can lead to strokes.

  

The Myth of Stents: Do They Actually Work?

Many people assume that getting a stent (a small tube inserted into the artery) will significantly improve their longevity. However, studies suggest that stents do not prolong life, but merely provide temporary relief from symptoms​.

The good news? There are several natural alternatives that can help clean out your arteries and reduce plaque safely.

15 Natural Ways to Reverse Plaque Buildup

1. High-Dose Melatonin

Surprisingly, melatonin (100mg nightly) has been shown in 121 research studies to reduce arterial plaque by lowering inflammation​. Watch my podcast on it here:

2. Lowering Blood Pressure (Below 120/70)

Keeping blood pressure low dramatically reduces vascular inflammation, preventing further plaque buildup​.

3. Optimizing Thyroid Function

Ensuring your FT3 thyroid hormone levels stay within the 4.0-4.8 range has been linked to plaque regression​.

4. Niacin (Vitamin B3) – 1,500-2,000 mg Daily

Niacin has been proven in 405 studies to reduce arterial plaque. While it may cause flushing, taking aspirin before niacin can minimize discomfort​.

5. Certain Statins (Only 2 Work!)

While many statins fail to reverse plaque, Simvastatin and Rosuvastatin (Crestor) have been shown to actively cause plaque regression. If you take a statin, supplementing with CoQ10 is crucial to prevent fatigue​.

6. Ezetimibe (10mg Daily, with a Statin)

This cholesterol-lowering drug enhances plaque regression when combined with a statin​.

7. Pioglitazone (Diabetes Medication)

This diabetes drug is the most powerful plaque regression tool available, clearing arteries in 3-6 months​.

8. PCSK9 Inhibitors (Repatha, Evolocumab)

A weekly injection that significantly reduces plaque buildup, although it is expensive​.

9. Estradiol (For Women)

Hormone replacement therapy in postmenopausal women reduces plaque and prevents heart attacks​.

10. Glutathione & GPX3 Activity

Glutathione, the body's master antioxidant, helps reduce oxidative stress and is linked to plaque regression. VARS Glutathione may support this process​.

11. Intermittent Fasting

Fasting reduces inflammation and improves cardiovascular health, with 190 studies supporting its role in plaque regression​.

12. High-Dose EPA (Fish Oil)

Omega-3 fatty acids, particularly high-dose EPA, have been shown to reduce plaque volume in coronary arteries​.

13. Bergamot Oil & Naringenin

These natural compounds lower cholesterol by up to 30% and have been shown in 31 studies to promote plaque regression​.

14. Exercise (10,000 Steps Daily)

Regular low-intensity cardio has been proven in 134 studies to reduce arterial plaque. Aim for at least 10,000 steps per day​.

15. Testosterone Optimization (For Men)

Maintaining healthy testosterone levels has been linked to improved cardiovascular health and reduced plaque​.

How Do You Know If You Have Plaque Buildup?

The best non-invasive tests for arterial plaque include:
✔ 64-Slice CT Angiogram – The most accurate test for detecting blockages.
✔ Calcium Score Test – Determines if you have hardened plaque.
✔ Homocysteine Blood Test – Elevated homocysteine levels indicate higher stroke & heart attack risk​.

The Best Natural Plan for Plaque Regression

If you’re looking for a simple, natural approach to reduce plaque, here’s where to start:

1️⃣ Check Your Blood Pressure & Calcium Score – Early detection is key.
2️⃣ Start High-Dose Melatonin & Niacin – These have the strongest natural research backing.
3️⃣ Optimize Thyroid & Testosterone Levels – Consult with a doctor if necessary.
4️⃣ Supplement with Glutathione & CoQ10 – Protect your arteries from oxidative damage.
5️⃣ Eat a Mediterranean Diet – Cut out processed foods and focus on anti-inflammatory nutrition.
6️⃣ Exercise Daily – Even 30 minutes of walking can make a difference.
7️⃣ Consider Natural Alternatives Like Bergamot & High-Dose EPA – These can safely lower cholesterol.

Take Control of Your Heart Health

Plaque regression is possible, and natural therapies can be just as effective—if not more so—than traditional medical interventions. By making simple lifestyle changes, you can reduce your risk of heart disease and live a longer, healthier life.

👉 Don’t wait until a heart attack or stroke happens—start taking action today!

• Niacin and Plaque Regression: A randomized controlled trial evaluated the benefit of adding extended-release niacin to statin therapy in older individuals with established atherosclerosis. The study found that while both groups experienced significant decreases in internal carotid artery wall volume, there was no additional benefit from adding niacin.

  pubmed.ncbi.nlm.nih.gov

• Pharmacologic Plaque Passivation: This review discusses various pharmacologic agents, including niacin, that may contribute to plaque passivation. The article highlights that lipid-modifying agents, antiplatelet agents, and antithrombotic agents can reduce the occurrence of acute coronary events in patients with acute coronary syndromes.

  pubmed.ncbi.nlm.nih.gov

• Calcification Reversal with EDTA-Tetracycline Therapy: A study explored the combination of EDTA and tetracycline (comET therapy) in patients with coronary artery disease. The results indicated that comET therapy led to a significant decrease in coronary artery calcium scores, suggesting regression of calcified coronary artery plaque volume.

  pubmed.ncbi.nlm.nih.gov