MTHFR - The Gene Error Most People Don't Know About
Chances are you have it too
Imagine a vast Inland Sea, a large body of shallow water stretching for hundreds of miles in one direction. Despite its size, you could walk about 50 miles into the water and still not be submerged. Although most of it appears lifeless, there are birds and other creatures visible. As you gaze further out, you notice the sea is surrounded by enormous mountains, forming a bowl-like shape.
This sea serves as a metaphor for the future of medicine. It symbolizes the unfolding discoveries of genetic diseases, similar to what we learned from the completion of the Human Genome Project in 2003. This groundbreaking milestone allowed us to compare normal gene structures with variations found in the population. Through this comparison, we identified numerous gene errors, defects, and transcription errors that affect our ability to produce essential enzymes within our cells. These errors hinder our utilization of certain vitamins, minerals, proteins, and amino acids at a cellular level.
Interestingly, naturopaths and practitioners focused on natural remedies and have embraced this knowledge, while many Western physicians have overlooked it. We, as Western physicians, have failed to recognize the widespread occurrence of genetic issues and instead prescribed temporary solutions. For example, some patients experience severe adverse reactions to prenatal vitamins or antidepressants, while others struggle with birth control pills. These reactions may be linked to specific genetic variations and transcription errors, rather than being random occurrences.
The Human Genome Project revealed the existence of thousands of gene mutations and transcription errors that pose significant health problems for individuals on a daily basis. One such example is the COMT gene, which, when deficient in liver methylation enzymes due to a genetic error, increases the risk of breast cancer by seven times. Moreover, there are more serious and underdiagnosed conditions like MTHFR, which affects up to 85% of the US population to some extent. This disorder, often misdiagnosed as chronic fatigue, depression, or schizophrenia, can lead to clotting issues and impact the effectiveness of birth control pills and SSRI medications.
Methylation, a critical process for energy production in the body, becomes impaired in individuals with methylation issues. This impairment prevents the adequate production of enzymes like MTHFR, which is crucial for methylating substances such as B12, pantothenic acid, magnesium, zinc, and copper. Additionally, it hampers detoxification processes and the production of glutathione, which is vital for eliminating toxins and heavy metals from the body. The significance of MTHFR-related diseases is evident in the high prevalence of two MTHFR genes among children with autism spectrum disorder, as they struggle to produce sufficient glutathione and are prone to heavy metal accumulation.
To those skeptical of these conditions, I present compelling laboratory evidence in my book, "The 85 Solution." Over the past 20 years since the Human Genome Project, we have gained much more knowledge about these conditions and their implications. However, our understanding is just scratching the surface, and there is an immense amount yet to be discovered in the vast sea of genetics. Younger physicians are urged to join me on this journey of understanding the genetics that will shape the future of medicine in the next century.
In "The 85 Solution," I delve into protocols for diagnosis, patient selection, and comprehensive treatment approaches. While these protocols are effective, they are continually evolving as our knowledge expands. The book serves as an ever-growing resource, and I will continue to update it as long as I live. I invite you to join me in exploring the depths of the Inland Sea, uncovering its secrets and learning more about MTHFR and the challenges faced by patients with methylation issues.
Make sure to check out my MTHFR Support supplements, both MTHFR RENEW and MTHFR ENDURE are available through physiciandesigned.com or Amazon.
MTHFR stands for methylenetetrahydrofolate reductase, which is an enzyme involved in the metabolism of folate (vitamin B9) in the body. The MTHFR gene provides instructions for producing this enzyme.
Genetic variations in the MTHFR gene can affect the activity or function of the enzyme. The most well-known genetic variants are known as MTHFR C677T and MTHFR A1298C. These variations can lead to reduced enzyme activity, impacting the body's ability to process folate efficiently.
The MTHFR enzyme is important for converting dietary folate into its active form, methylfolate. Methylfolate plays a crucial role in various biological processes, including DNA synthesis, methylation reactions, neurotransmitter synthesis, and detoxification processes.
Certain MTHFR gene variants have been associated with potential health implications, although the significance and clinical relevance of these associations are still the subject of ongoing research. Some of the conditions and concerns that have been linked to MTHFR gene variants include:
Hyperhomocysteinemia: Reduced MTHFR enzyme activity can lead to elevated levels of homocysteine, an amino acid associated with increased cardiovascular disease risk.
Neural tube defects: Certain MTHFR gene variants have been associated with a slightly increased risk of neural tube defects, which are birth defects affecting the development of the brain and spinal cord in newborns.
Pregnancy complications: Some research suggests that MTHFR gene variants may be associated with an increased risk of pregnancy complications, such as preeclampsia, recurrent miscarriages, and fetal growth restriction. However, the evidence is still limited, and the relationship is not fully understood.
It's important to note that having MTHFR gene variants does not necessarily mean that a person will develop health problems or experience symptoms. Genetic testing for MTHFR gene variants is available, but it's essential to interpret the results in consultation with a healthcare professional who can provide personalized advice based on individual circumstances.
If you have concerns about MTHFR gene variants or their potential impact on your health, reach out to my clinic and let’s get started on your wellness journey.
DanPurserMD.com 801-796-7667 or info@danpursermd.com