High Dose Melatonin, a new Anti Inflammatory?
New Research and Studies to Check Out
Melatonin is a hormone that is naturally produced in the body and is involved in regulating the sleep-wake cycle. While melatonin is commonly used as a sleep aid, some people may wonder about the potential benefits of high dose melatonin. Here are a few possible benefits of high dose melatonin:
Antioxidant effects: Melatonin has been shown to have antioxidant effects, which can help protect against damage caused by free radicals. Some studies suggest that high dose melatonin may have even stronger antioxidant effects than lower doses.
Immune system support: Melatonin may also have immune system-boosting effects. Some studies have shown that high dose melatonin may help to stimulate the immune system and improve overall immune function.
Neuroprotective effects: Melatonin has been shown to have neuroprotective effects, which can help to protect the brain and nervous system from damage. Some studies suggest that high dose melatonin may be particularly effective in protecting against neurodegenerative diseases such as Alzheimer's and Parkinson's.
Sleep regulation: High dose melatonin may also be effective for regulating sleep patterns in people with certain sleep disorders. Some studies have suggested that high doses of melatonin may be more effective than lower doses for treating insomnia and other sleep disorders.
While high dose melatonin may have some potential benefits, it's important to note that taking too much melatonin can also have negative side effects, such as daytime sleepiness, dizziness, and headaches. It's always best to speak with your healthcare provider before taking high doses of melatonin or any other supplement to determine if it's safe and appropriate for you.
That being said, I have tried High Dose Melatonin for myself and have have a great experience.
My results of 60-100mg at night of melatonin? All inflammation gone. Severe osteoarthritis pain in lower back completely resolved and gone. Feel like I am 30 (I am 60+). Also I have no myalgias even after working out or working in my garage or doing anything. It feels like I took two naproxen 220 mg twice a day, but have not (I rarely take that but only when my pain is above a 5 (like 6-8). Melatonin seems extremely anti-aging. I feel very good on it. (Note that it did take me about 30-40 days to get to this dose.)
No contraindications or side effects. In a study cited below participants were give 300mg a night of quick release (not extended or slow release) melatonin for two years without significant side effects (some rare day time drowsiness was noted by a few of the participants).
This may be a good option for you…
Click here for link to 20-100mg Melatonin options from Amazon.
Scientific Studies to look at:
HELPS MAINTAIN HEALTHY CARTILAGE https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935446/
Melatonin and its relation to the immune system and inflammation https://pubmed.ncbi.nlm.nih.gov/11268363/#:~:text=Melatonin%20has%20been%20shown%20to,macromolecular%20damage%20in%20all%20organs.
Anti-inflammatory effects of Melatonin: A mechanistic review https://pubmed.ncbi.nlm.nih.gov/29902071/
Melatonin improved SOD and GPx activity https://pubmed.ncbi.nlm.nih.gov/30173656/
Melatonin increases CuZnSOD after long term hypokinesis https://pubmed.ncbi.nlm.nih.gov/20701024/
Melatonin causes SOD level maintenance https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.2007.00505.x
***High dose melatonin as cancer adjuvant (slideshow,and easiest to read) https://riordanclinic.org/wp-content/uploads/2019/03/3-3-Shallenberger-High-Dose-Melatonin-Therapy-An-Ideal-Adjuvant.pdf
Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901806/
PubMed search of MELATONIN ARTHRITIS (many great studies articles) https://www.ncbi.nlm.nih.gov/pmc/?term=Melatonin+arthritis
PubMed search of MELATONIN CVD (cardio vascular disease) https://www.ncbi.nlm.nih.gov/pmc/?term=Melatonin+CVD
PubMed search of MELATONIN CANCER https://www.ncbi.nlm.nih.gov/pmc/?term=Melatonin+CAncer
PubMed search of MELATONIN FIBROMYALGIA https://www.ncbi.nlm.nih.gov/pmc/?term=Melatonin+Fibromyalgia
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway https://pubmed.ncbi.nlm.nih.gov/35803929/
Anti-Inflammatory Effects of Melatonin: A Systematic Review and Meta-Analysis of Clinical Trials